The Dunkin Hartley is the most common guinea pig strain used in biomedical research, particularly for studies of asthma, allergy, infectious disease, reproduction, and osteoarthritis. Further studies are needed to determine specific risk factors and identify possible preventative measures. The need for surgical intervention should not confer a poorer outcome. A poorer prognosis was associated with older, male guinea pigs, and those displaying anorexia, weight loss, and hypothermia. In particular, distal urinary tract urolithiasis should be considered in females. Urolithiasis should always be considered a differential diagnosis for any unwell guinea pig. Reoccurrence was noted in 13.9% (22/158) of cases, at an average of 284 days. Surgical intervention was not a risk factor for nonsurvival however, increased age (> 4.1 years), male sex, anorexia, weight loss, and lower rectal temperature (< 37.2 ☌) on presentation were associated with nonsurvival. Females more commonly presented with distal urinary tract urolithiasis (63/84 75%) but fared better overall with a longer median survival time (1,149 days) than males (59 days). In 81 of 154 (52.5%) cases, animals were presented with primary urinary concerns, while 73 (47.5%) presented for nonurinary primary concerns. Males were presented younger (mean age, 3.64 years) than females (4.41 years). ![]() Overall, 54.4% (86/158) of animals survived to discharge. Variables of interest were analyzed for statistical associations with outcome. Signalment, clinical data, and outcomes were recorded. Medical records of an exotics animal specialty service were searched, identifying guinea pigs with urolithiasis. To investigate risk factors, clinical features, and prognostic indicators in guinea pigs with urolithiasis.
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